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Profa. Dra. Anita E. Mattson

Department of Chemistry and Biochemistry – The Ohio State University

Data: 24 de fevereiro de 2014

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The advancement of hydrogen bond donor (HBD) organocatalysis has been inhibited by a number of challenges.  Conventional HBDs suffer from high catalyst loadings and operate in only limited types of reactions, typically the activation of 1,2- and 1,4-acceptors for nucleophilic attack.  To address the shortcomings of HBD catalysis our group is investigating the design and application of innovative catalysts with improved reactivity.  Specifically, boronate ureas and silanediols are being developed as two new families of enhanced HBD catalysts that are capable of promoting and controlling unique reactions, such as metal-free insertions, multicomponent couplings, arylations and cross-couplings. Details behind the development of boronate urea and silanediol catalysis, including plausible mechanisms of action, will be presented.

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Currículo resumido:

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Anita Mattson received her B.S. from Northern Michigan University in 2002 where she studied polarity reversal catalysis in the context of radical reactions with Professor Frankie Ann McCormick.  As a graduate student at Northwestern University she joined the group of Professor Karl Scheidt and developed new thiazolium-based strategies for acyl anion addition reactions.  In 2007 she completed her Ph.D. and became an NIH postdoctoral fellow in Professor Michael Crimmins’ group at the University of North Carolina at Chapel Hill where she investigated a highly convergent approach toward hemibrevetoxin B.  Mattson joined the faculty of The Ohio State University in 2009 as an assistant professor in the Department of Chemistry.  Her current research interests include the strategic design and application of new organic catalysts in innovative methodologies.

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