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Prof. Dr. ULRICH ABRAM  e  Sra. CHRISTINA PETERS

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Alemanha

“Free University of Berlin in General” – Sra. Christina Peters

“Chemistry at Free University of Berlin” – Prof. Dr. Ulrich Abram

Data: 18 de setembro de 2013

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The metastable technetium nuclide 99mTc is the workhorse in nuclearmedical routine diagnostics, while the radioactive
rhenium isotopes 186Re and 188Re are promising candidates for radiotherapy. The development of novel
pharmaceuticals on the basis of these nuclides requires exact knowledge of the coordination chemistry of the
corresponding elements.
The seminar talk gives an overview about the present status of nuclearmedical appplications with the two element
and modern research trends in this field. The composition of the routinely used kits of the major Tc pharmaceuticals
are introduced and the coordination chemistry of the drugs are explained.

The second part of the talk covers the research, which is currently done in the Radiochemistry group of Freie
Universität Berlin. This includes the synthesis of novel organometallic compounds of technetium and rhenium
with N-heterocyclic carbenes and aryl ligands and their potential use in nuclear medical applications as well as
strategies for the labeling of macromolecules such as peptides or proteins. For the latter purpose, multidentate
ligand systems are developed, which provide stability to the coordinated metal cores and allow conjugation to
biologically active molecules, e.g. by ‘peptide couplings’ or ‘Click’ reactions. Structural features of the corresponding
ligands, complexes and bioconjugates are discussed together with synthetic aspects.